Integrin‐linked kinase KO mice display abnormal liver histology and hepatomegaly following partial hepatectomy
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منابع مشابه
Delayed liver regeneration after partial hepatectomy in adiponectin knockout mice.
We previously demonstrated that adiponectin has anti-fibrogenic and anti-inflammatory effects in the liver of mouse models of various liver diseases. However, its role in liver regeneration remains unclear. The aim of this study was to determine the role of adiponectin in liver regeneration. We assessed liver regeneration after partial hepatectomy in wild-type (WT) and adiponectin knockout (KO)...
متن کاملPartial hepatectomy induced liver proteome changes in mice.
Acceleration of liver regeneration could be of great clinical benefit in various liver-associated diseases. However, at present little is known about therapeutic interventions to enhance this regenerative process. Our limited understanding and the complexity of the mechanisms involved have prevented the identification of new targets for treatment. Here we propose a broad-range proteomic approac...
متن کاملHeat-shock pre-treatment reduces liver injury and aids liver recovery after partial hepatectomy in mice.
BACKGROUND Heat-shock proteins (HSPs) are members of a chaperone protein family reported to modify stress responses. The aim of this study was to clarify the hypothesis of whether pre-treatment with heat shock reduces liver damage and influences liver regeneration after partial hepatectomy. MATERIALS AND METHODS Mice (N=6) were divided into two groups: the control group underwent partial hepa...
متن کاملdelayed liver regeneration after partial hepatectomy in aged nos2 knockout mice
objective: patients over 60 years of age have higher mortality and morbidity after major liver resections. nitric oxide (no) derived from the catalytic activity of nos2 plays a beneficial role in liver regeneration (lr) after partial hepatectomy (ph). in this experiment, we evaluated the effect of nos2 knockout (ko) on lr in aged mice after ph. materials and methods: in this cohort study, 52 tw...
متن کاملRegeneration of mouse liver after partial hepatectomy.
The rapidly growing liver tissue after partial hepatectomy has been used advantageously by in vestigators to study changes during accelerated growth and proliferation of cells (4, 7, 12, 15). Previous reports have been chiefly on rats. In many instances, pooled samples were taken for chemical data. In the present investigation a com prehensive study was made on individual samples of regeneratin...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.22.1_supplement.465.9